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職位描述：

崗位職責(zé)：
1、負(fù)責(zé)蛋白質(zhì)工程、微生物代謝工程、合成生物學(xué)等項(xiàng)目研發(fā)；
2、進(jìn)行項(xiàng)目文獻(xiàn)調(diào)研、實(shí)驗(yàn)計(jì)劃的制定、技術(shù)指標(biāo)的實(shí)現(xiàn)、項(xiàng)目文檔的撰寫(xiě)等；
3、配合實(shí)驗(yàn)室日常管理工作，包括實(shí)驗(yàn)室儀器的日常保養(yǎng)和維護(hù)、實(shí)驗(yàn)室菌株資源維護(hù)，建立并管理相應(yīng)文檔等；
4、編制并維護(hù)實(shí)驗(yàn)室各類技術(shù)操作規(guī)程，協(xié)助教師對(duì)學(xué)生進(jìn)行定期技術(shù)培訓(xùn)；
5、完成團(tuán)隊(duì)負(fù)責(zé)人安排的其它工作。

崗位要求：
1、生物化學(xué)、生物工程、分子生物學(xué)等相關(guān)專業(yè)碩士畢業(yè)，或在相關(guān)專業(yè)本科畢業(yè)后，熟悉枯草芽孢桿菌表達(dá)系統(tǒng)，具有1年以上研究經(jīng)歷；
2、具有事業(yè)心，善于開(kāi)拓進(jìn)取，善于溝通，能吃苦耐勞，具有獨(dú)立開(kāi)展課題的能力，具有強(qiáng)烈的團(tuán)隊(duì)協(xié)作精神。


三、待遇
1.固定工資 績(jī)效獎(jiǎng)勵(lì)，具體金額根據(jù)個(gè)人情況面議；
2.享受5險(xiǎn)1金及學(xué)校規(guī)定的其它待遇。


一、實(shí)驗(yàn)室簡(jiǎn)介：
分子酶學(xué)與合成生物學(xué)實(shí)驗(yàn)室依托于上海交通大學(xué)微生物代謝國(guó)家重點(diǎn)實(shí)驗(yàn)室，負(fù)責(zé)人是馮雁教授（973項(xiàng)目首席科學(xué)家、生命學(xué)院院長(zhǎng)、國(guó)家重點(diǎn)實(shí)驗(yàn)室副主任），課題組其它成員包括楊廣宇研究員、崔莉副研究員、張勇副研究員、劉倩副研究員。
實(shí)驗(yàn)室致力于解析微生物關(guān)鍵代謝酶的結(jié)構(gòu)、催化機(jī)制與進(jìn)化規(guī)律，發(fā)展蛋白質(zhì)分子進(jìn)化與合成生物學(xué)技術(shù)，針對(duì)實(shí)際應(yīng)用需求對(duì)關(guān)鍵酶進(jìn)行分子設(shè)計(jì)與定向進(jìn)化，以期提高酶對(duì)非天然底物的選擇性、催化效率及其對(duì)環(huán)境的適應(yīng)性等，進(jìn)而構(gòu)建高效、特異的進(jìn)化酶與人工合成途徑。
實(shí)驗(yàn)室承擔(dān)了國(guó)家重點(diǎn)研發(fā)計(jì)劃，國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目，國(guó)家973計(jì)劃項(xiàng)目、863項(xiàng)目、自然科學(xué)基金委重大儀器專項(xiàng)等研究任務(wù)。在Science Adv., Nature Commun., Angew. Chem., JACS, JBC, ACS Synth. Biol., 等著名雜志發(fā)表多篇論文。

近5年代表性論文：
1) Z Li, Y Deng, GY Yang. Growth-coupled high throughput selection for directed enzyme evolution. Biotechnology Advances, 2023, 68, 108238
2) X Jin, GY Yang. Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases. Progress in Lipid Research, 2023, 91, 101241
3) Jingjie Jiang, Guangyu Yang*, Fuqiang Ma*. Fluorescence coupling strategies in fluorescence-activated droplet sorting (FADS) for ultrahigh-throughput screening of enzymes, metabolites, and antibodies. Biotechnol Adv, 2023, 66:108173.
4) B He, X Bai, Y Tan, W Xie, Y Feng, GY Yang. Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products. Synthetic and Systems Biotechnology. 2022, 7 (1), 602-620
5) X Chen, X Jin, F Huang, J Wang, X Cao, PG Wang, Y Feng, F Jiang, GY Yang*. Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety. European Journal of Medicinal Chemistry. 2022, 241, 114636
6) X Bai, D Li, F Ma, X Deng, M Luo, Y Feng, G Yang*. Improved thermostability of creatinase from Alcaligenes Faecalis through non-biased phylogenetic consensus-guided mutagenesis. Microbial cell factories, 2020, 19 (1), 1-13
7) Xi Deng, Liuqing Chen, Mohan Hei, Tiangang Liu, Yan Feng, Guang-Yu Yang*. Structure-guided Reshaping of the Acyl Binding Pocket of 'TesA Thioesterase Enhances Octanoic Acid Production in E. Coli, Metab Eng. 2020, 61:24-32.
8) Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang. Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method. Science Advances, 2019, eaaw8451
9) Fuqiang Ma#, Meng Ting Chung#, Yuan Yao, Robert Nidet, Lap *** Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi*, Guang-Yu Yang*. Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform. Nature Communications, 2018, 9:1030. (#equal contribution)